Comparative antioxidant and antimicrobial properties of Lentinula edodes Donko and Koshin varieties against priority multidrug-resistant pathogens

The problematic increase in multidrug-resistant bacteria translates into the urgent need to discover novel and effective antimicrobial substances. Herein, mushrooms could be a promising alternative of natural source new antimicrobials. present work aimed compare phytochemical composition activity methanol aqueous crude extracts Lentinula edodes var. Koshin Donko. Disk diffusion method was used screen assess synergistic effect mushroom extracts. Microdilution determine minimum inhibitory concentration (MIC) bactericidal (MBC). Phytochemical characterization achieved by analysis total phenols, ortho-diphenols content its antioxidant activity. results noticed positive relation between phenolic compounds content, activity, capacity mushroom's L. extracts, which contained highest amount compounds, exhibited scavenging ABTS which, turns, efficacy inhibiting growth methicillin-resistant Staphylococcus aureus. Moreover, combination commercial antibiotics showed favorable effects against tested bacteria. These suggest that may represent an important valuable therapeutic